The Opportunity

Underdog Pharmaceuticals is a pharmaceutical startup developing drugs targeting the diseases and disabilities of aging. Underdog is looking for an exceptional in vivo research associate/senior research associate to join our team. Underdog is engineering drugs that can bind and reverse the pathological effects of oxidized cholesterol implicated in atherosclerosis and several other diseases of aging. Our 1st drug candidate is moving rapidly towards human clinical trials. We are in search of an in vivo research associate/senior research associate to participate in the design and execution of in vivo, in vitro, and ex vivo assays establishing safety and efficacy of compounds destined for clinical evaluation. Applicants should have a BS or MS degree in biochemistry, cell biology or a related biomedical field and substantial independent laboratory research experience (in addition to laboratory course work) with the following techniques:

• Rodent handling (primarily mouse, rat experience is secondarily desirable)
• Animal husbandry
  • Maintenance of genetic knockout strains
  • Normal upkeep of vivarium (cage changes, animal monitoring, etc.
• Administration of test compounds (iv, ip, sq, and im injections and oral gavage)
• Blood collection (cardiac puncture, submandibular)
• Necropsy (organ removal and examination, fixation of samples for histological analysis)
• Rigorous upkeep of laboratory notebooks
• Laboratory reagent and solution preparation

Additional experience in the following techniques will strengthen applications:

• Mammalian cell culture
• 96-well plate assays using a plate reader spectrophotometer
• Fluorescence microscopy imaging
• Experience working with cholesterol and other natural and oxidized sterols

This position represents the opportunity to join a small, dynamic, interdisciplinary team and will require the following personality traits:

• Excellent interpersonal and organizational skills
• Ability to communicate effectively, both orally and in writing, in a cross-disciplinary team
• Self-starter who can take initiative while integrating into the workflow and goals of the team
• Excellent analytical and problem-solving skills
• Ability to work in a collegial manner while being highly tolerant and respectful of all members of a small interdisciplinary team
• Focused and goal-oriented, yet flexible enough to deal with unanticipated challenges and opportunities

Underdog Pharmaceuticals offers competitive compensation packages including salary commensurate with experience, paid vacation and sick leave, health insurance benefits, and early equity opportunities. Further information on Underdog Pharmaceuticals can be found at www.underdogpharma.com. Relocation benefits will not be provided for this position. Underdog Pharmaceuticals is an equal opportunity employer.

Please send resume and cover letter to jobs@underdogpharma.com

• Principals only. Recruiters, please don’t contact this job poster.
• Do NOT contact us with unsolicited services or offers.

Underdog Pharmaceuticals, a startup-level pharmaceutical company embedded in the SENS Research Foundation, is looking for an exceptional research associate to join our team. Underdog is engineering drugs that can bind and reverse the pathological effects of certain oxidized forms of cholesterol implicated in atherosclerosis and several other diseases of aging. We are in search of a research associate to participate in the design and execution of in vitro and ex vivo assays establishing safety and efficacy of compounds destined for clinical evaluation. Applicants should have a BS degree in biochemistry, cell biology or a related biomedical field and substantial independent laboratory research experience (in addition to laboratory course work) with the following techniques:

• Mammalian cell culture
• 96-well plate assays using a plate reader spectrophotometer
• Rigorous upkeep of laboratory notebooks
• Laboratory reagent and solution preparation

Additional experience in the following techniques will strengthen applications:

• PBMC isolation from fresh whole blood (human and other mammalian species)
• Utilization of an automated (robotic) liquid handler to run 96-well plate assays
• Fluorescence microscopy imaging
• Culturing, differentiation, and polarization of macrophages towards the goal of creating foam cells
• Flow cytometry analysis and characterization of macrophages
• Experience working with cholesterol and other natural and oxidized sterols
• Assay development experience

This position represents the opportunity to join a small, dynamic, interdisciplinary team and will require the following personality traits:

• Excellent interpersonal and organizational skills
• Ability to communicate effectively, both orally and in writing, in a cross-disciplinary team
• Self-starter who can take initiative while integrating into the workflow and goals of the team
• Excellent analytical and problem-solving skills
• Ability to work in a collegial manner while being highly tolerant and respectful of all members of a small interdisciplinary team
• Focused and goal-oriented, yet flexible enough to deal with unanticipated challenges and opportunities

Underdog Pharmaceuticals offers competitive compensation packages including salary commensurate with experience, paid vacation and sick leave, health insurance benefits, and early equity opportunities. Further information on Underdog Pharmaceuticals can be found at www.underdogpharma.com. Relocation benefits will not be provided for this position. Underdog Pharmaceuticals is an equal opportunity employer.

Please send resume and cover letter to jobs@underdogpharma.com

• Principals only. Recruiters, please don’t contact this job poster.
• Do NOT contact us with unsolicited services or offers.