7-Ketocholesterol in disease and aging

Hydroxypropyl Beta Cyclodextrin molecule

Scientists from Underdog Pharmaceuticals, in conjunction with Professor Jay Jerome of Vanderbilt University Medical Center, have published an article in the journal Redox Biology, covering the role of the toxic biomolecule 7-ketocholesterol, especially in the development of diseases of aging.

You can find the open access link here:
  

Abstract

7-Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and disabilities of aging, as well as several orphan diseases. 7KC is the most common product of a reaction between cholesterol and oxygen radicals and is the most concentrated oxysterol found in the blood and arterial plaques of coronary artery disease patients as well as various other disease tissues and cell types. Unlike cholesterol, 7KC consistently shows cytotoxicity to cells and its physiological function in humans or other complex organisms is unknown. Oxysterols, particularly 7KC, have also been shown to diffuse through membranes where they affect receptor and enzymatic function. Here, we will explore the known and proposed mechanisms of pathologies that are associated with 7KC, as well speculate about the future of 7KC as a diagnostic and therapeutic target in medicine.

Share on facebook
Share on twitter
Share on reddit
Share on linkedin
Share on whatsapp
Share on email

Underdog News:

7-Ketocholesterol in disease and aging

Scientists from Underdog Pharmaceuticals, in conjunction with Professor Jay Jerome of Vanderbilt University Medical Center, have published an article in the journal Redox Biology, covering the role of the toxic biomolecule 7-ketocholesterol, especially in the

Read More »

© 2020 Underdog Pharmaceuticals – ALL RIGHTS RESERVED

Site developed by Moonburn.com

© 2019 Underdog Pharmaceuticals – ALL RIGHTS RESERVED

Site developed by Moonburn.com